Aridol

Generic Name: mannitol (Inhalation route)

MAN-i-tol

Inhalation route(Powder)

Mannitol acts as a bronchoconstrictor and may cause severe bronchospasm. Mannitol bronchial challenge testing is for diagnostic purposes only and should be conducted only by trained professionals under a physician familiar with the test and management of acute bronchospasm (ie, testing area equipped with appropriate medications and equipment). Immediately administer a short-acting inhaled beta-agonist in the event of severe bronchospasm. Do not perform bronchial challenge testing with mannitol in a patient with asthma or very low baseline pulmonary function tests (eg, FEV1 less than 1 to 1.5 L or less than 70% of the predicted values) .

Commonly used brand name(s)

In the U.S.

• Aridol

Available Dosage Forms:

• Capsule

Pharmacologic Class: Diuretic, Osmotic

Uses For Aridol

Mannitol inhalation is used in patients 6 years of age and older to help diagnose asthma. It is used in a procedure called bronchial challenge test to help your doctor measure the effect of this medicine on your lungs and check if you have difficulty with breathing.

This medicine is to be given only by or under the immediate supervision of your doctor.

Before Using Aridol

In deciding to use a diagnostic test, any risks of the test must be weighed against the good it will do. This is a decision you and your doctor will make. Also, other things may affect test results. For this test, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of mannitol inhalation in children 6 years of age and older. However, mannitol inhalation should not be given to children younger than 6 years of age.

Geriatric

Appropriate studies have not been performed on the relationship of age to the effects of mannitol inhalation in the geriatric population. Safety and efficacy have not been established.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this diagnostic test, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Receiving this diagnostic test with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Arsenic Trioxide


• Droperidol


• Levomethadyl


• Sotalol

Receiving this diagnostic test with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Licorice

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this diagnostic test. Make sure you tell your doctor if you have any other medical problems, especially:

• Angina (severe chest pain), unstable or


• Cough, severe or


• Hemoptysis (coughing up blood) or


• Infection (e.g., upper and lower respiratory tract) or


• Lung disease or other breathing problems (e.g., ventilatory impairment) or


• Pneumothorax (air or gas in the chest cavity) or


• Spirometry-induced bronchoconstriction (breathing problem during the spirometry test) or


• Surgery (e.g., stomach, chest, or eyes), recent—Use with caution. May make these conditions worse.

• Aortic or cerebral aneurysm (heart or blood vessel problem) or


• Heart attack, recent or


• Hypertension (high blood pressure), uncontrolled or


• Stroke, recent—Should not be used in patients with these conditions. May cause bronchospasm.

• Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of Aridol

Inhaled mannitol is used with a special inhaler which will measure the effect of this medicine on your lungs. It is given by a doctor or other trained health professional who will be with you during the test. After you have completed the test, your doctor will know the result right away (positive or negative for asthma).

Aridol™ is a test kit containing one single patient use inhaler and 3 blister packs containing 19 capsules of mannitol for inhalation in marked doses to perform one bronchial challenge test.

Do not put the capsules in your mouth or swallow them.

To perform the test:

• Before doing the bronchial challenge test, your doctor may ask you to perform a breathing or lung test (e.g., spirometry test).


• A nose clip will then be put on your nose so you will only able to breathe in and out of your mouth.


• Place 0 mg capsule into the inhaler. Press the side buttons of the inhaler once to puncture the capsule.


• To inhale this medicine, breathe out fully, trying to get as much air out of the lungs as possible. Put the inhaler just in front of your mouth.


• Open your mouth and breathe in slowly and deeply (like yawning).


• Hold your breath for about 5 seconds, then breathe out slowly before removal of the nose clip.


• You will be asked to repeat the above steps up to 8 times (total of 9 increasing doses of Aridol™). This is to measure the effect of Aridol™ in your lungs.


• Once you have finished the test, you will be given a short-acting inhaler to help you breathe (for patients who have a positive result).


• Throw away the inhaler after using.

Precautions While Using Aridol

Your doctor will check you closely while doing the bronchial challenge test. This will allow your doctor to see if the medicine is working properly and to check for any unwanted effects.

This medicine may cause severe bronchospasm. Tell your doctor right away if you are having a cough, difficulty with breathing, shortness of breath, or wheezing after receiving this medicine. Your doctor will give you a short-acting inhaler right away to treat your symptoms.

Aridol Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common

• Chest discomfort


• cough


• difficult or labored breathing


• dry heaves


• runny nose


• shortness of breath


• sore throat


• tightness in the chest


• troubled breathing


• vomiting


• wheezing

Incidence not known

• Gagging

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Headache

Less common

• Dizziness


• nausea


• sore throat

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Aridol side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Aridol resources

• Aridol Side Effects (in more detail)
• Aridol Use in Pregnancy & Breastfeeding
• Aridol Drug Interactions
• Aridol Support Group
• 0 Reviews for Aridol - Add your own review/rating

• Aridol Consumer Overview


• Mannitol Monograph (AHFS DI)


• Mannitol MedFacts Consumer Leaflet (Wolters Kluwer)


• Osmitrol Prescribing Information (FDA)

Compare Aridol with other medications

• Diagnosis and Investigation

Niravam Orally Disintegrating Tablets

Pronunciation: al-PRA-zoe-lam
Generic Name: Alprazolam
Brand Name: Niravam

Niravam Orally Disintegrating Tablets are used for:

Treating anxiety and panic disorder. It may also be used to treat other conditions as determined by your doctor.

Niravam Orally Disintegrating Tablets are a benzodiazepine. It works in the brain to decrease anxiety.

Do NOT use Niravam Orally Disintegrating Tablets if:

• you are allergic to any ingredient in Niravam Orally Disintegrating Tablets or other benzodiazepines (eg, diazepam)


• you have acute narrow-angle glaucoma


• you are taking delavirdine, itraconazole, ketoconazole, or sodium oxybate (GHB)

Contact your doctor or health care provider right away if any of these apply to you.

Video: Treatment for Depression

Treatments for depression are getting better everyday and there are things you can start doing right away.

Before using Niravam Orally Disintegrating Tablets:

Some medical conditions may interact with Niravam Orally Disintegrating Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are able to become pregnant


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of seizures, glaucoma or increased pressure in the eye, kidney or liver problems, lung or breathing problems (eg, chronic obstructive pulmonary disease [COPD], sleep apnea), myasthenia gravis, or a blood disorder known as porphyria


• if you have a history of other mental or mood problems (eg, depression), alcohol or other substance abuse or dependence, or suicidal thoughts or actions


• if you are in poor health, are very overweight, or are experiencing abnormal muscle movements


• if you drink alcoholic beverages or you smoke

Some MEDICINES MAY INTERACT with Niravam Orally Disintegrating Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Methadone because it may increase the risk of serious and sometimes fatal breathing problems


• Amiodarone, azole antifungals (eg, itraconazole, ketoconazole), cimetidine, cyclosporine, delavirdine, diltiazem, ergot alkaloids (eg, ergotamine), fluoxetine, fluvoxamine, isoniazid, macrolide antibiotics (eg, clarithromycin, erythromycin), nefazodone, nicardipine, nifedipine, omeprazole, oral contraceptives (birth control pills), paroxetine, propoxyphene, protease inhibitors (eg, boceprevir, ritonavir), sodium oxybate (GHB), telithromycin, or valproic acid because they may increase the risk of Niravam Orally Disintegrating Tablets's side effects


• Carbamazepine, rifamycins (eg, rifampin), or St. John's wort because they may decrease Niravam Orally Disintegrating Tablets's effectiveness


• Hydantoins (eg, phenytoin) because the risk of their side effects may be increased and they may decrease Niravam Orally Disintegrating Tablets's effectiveness


• Clozapine or tricyclic antidepressants (eg, desipramine, imipramine) because the risk of their side effects may be increased by Niravam Orally Disintegrating Tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if Niravam Orally Disintegrating Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Niravam Orally Disintegrating Tablets:

Use Niravam Orally Disintegrating Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Niravam Orally Disintegrating Tablets may be taken with or without food. If stomach upset occurs, take with food to reduce stomach irritation.


• Do not remove the blister from the outer pouch until you are ready to take Niravam Orally Disintegrating Tablets. Make sure that your hands are dry when you open the blister pack. Do not push the tablet through the foil. Peel back the foil on the blister pack and place the tablet on your tongue. The tablet dissolves quickly and can be swallowed with saliva. Niravam Orally Disintegrating Tablets may be taken with or without water. Take the tablet immediately after opening the blister pack. Do not store the removed tablet for future use. If you are only taking a half tablet for your dose, throw away the other half. Do not save it for later use.


• If you are taking Niravam Orally Disintegrating Tablets regularly, do not suddenly stop taking it without checking with your doctor. You may have an increased risk of side effects (eg, seizures). If you need to stop Niravam Orally Disintegrating Tablets or add a new medicine, your doctor will gradually lower your dose.


• Eating grapefruit or drinking grapefruit juice may affect the amount of Niravam Orally Disintegrating Tablets in your blood. Talk with your doctor before including grapefruit or grapefruit juice in your diet.


• If you miss a dose of Niravam Orally Disintegrating Tablets and you are using it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Niravam Orally Disintegrating Tablets.

Important safety information:

• Niravam Orally Disintegrating Tablets may cause drowsiness, dizziness, light-headedness, or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Niravam Orally Disintegrating Tablets. Using Niravam Orally Disintegrating Tablets alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.


• Do not drink alcohol while you are using Niravam Orally Disintegrating Tablets.


• Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Niravam Orally Disintegrating Tablets; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.


• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.


• Smoking may decrease Niravam Orally Disintegrating Tablets's effectiveness. Tell your doctor if you smoke or if you have recently stopped smoking.


• Tell your doctor or dentist that you take Niravam Orally Disintegrating Tablets before you receive any medical or dental care, emergency care, or surgery.


• Use Niravam Orally Disintegrating Tablets with caution in the ELDERLY; they may be more sensitive to its effects, especially decreased coordination and drowsiness.


• Use Niravam Orally Disintegrating Tablets with extreme caution in CHILDREN younger than 18 years of age; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Niravam Orally Disintegrating Tablets may cause harm to the fetus. If you think you may be pregnant, discuss with your doctor the benefits and risks of using Niravam Orally Disintegrating Tablets during pregnancy. Niravam Orally Disintegrating Tablets are found in breast milk. Do not breast-feed while taking Niravam Orally Disintegrating Tablets.

When used for long periods of time or at high doses, Niravam Orally Disintegrating Tablets may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Niravam Orally Disintegrating Tablets stops working well. Do not take more than prescribed.

Some people who use Niravam Orally Disintegrating Tablets may develop a need to continue taking it. People who take higher doses (eg, some patients with panic disorder) or use Niravam Orally Disintegrating Tablets for a long time have a greater risk. This is known as DEPENDENCE or addiction. If you stop taking Niravam Orally Disintegrating Tablets suddenly, you may have WITHDRAWAL symptoms. These may include blurred vision; burning, numbness, or tingling; changes in smell or other senses; decreased appetite; decreased awareness of your surroundings; decreased concentration; diarrhea; muscle cramps or twitches; seizures; or weight loss.

Possible side effects of Niravam Orally Disintegrating Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Changes in appetite; constipation; decreased sexual desire or ability; diarrhea; dizziness; drowsiness; dry mouth; light-headedness; nausea; tiredness; weight changes.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); behavior changes; blurred vision; burning, numbness, or tingling; chest pain; confusion; dark urine; decreased coordination; decreased urination; fainting; fast or irregular heartbeat; hallucinations; loss of balance or muscle control; memory or attention problems; menstrual changes; muscle twitching; new or worsening mental or mood changes (eg, depression, irritability, anxiety; exaggerated feeling of well-being); overstimulation; red, swollen blistered, or peeling skin; severe or persistent dizziness, drowsiness, or light-headedness; shortness of breath or trouble breathing; suicidal thoughts or actions; tremor; trouble speaking; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Niravam side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include confusion; loss of consciousness; loss of coordination; severe drowsiness or deep sleep; slow reflexes.

Proper storage of Niravam Orally Disintegrating Tablets:

Store Niravam Orally Disintegrating Tablets at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Niravam Orally Disintegrating Tablets out of the reach of children and away from pets.

General information:

• If you have any questions about Niravam Orally Disintegrating Tablets, please talk with your doctor, pharmacist, or other health care provider.


• Niravam Orally Disintegrating Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Niravam Orally Disintegrating Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Niravam resources

• Niravam Side Effects (in more detail)
• Niravam Use in Pregnancy & Breastfeeding
• Drug Images
• Niravam Drug Interactions
• Niravam Support Group
• 12 Reviews for Niravam - Add your own review/rating

Compare Niravam with other medications

• Anxiety
• Depression
• Dysautonomia
• Panic Disorder
• Tinnitus

Azopt

Generic Name: Brinzolamide
Class: Carbonic Anhydrase Inhibitors
Chemical Name: (R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide
Molecular Formula: C₁₂H₂₁N₃O₅S₃
CAS Number: 138890-62-7

Introduction

Carbonic anhydrase inhibitor;^{2 4 6} nonbacteriostatic sulfonamide derivative.¹

Uses for Azopt

Ocular Hypertension and Glaucoma

Reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.^{1 3 4 5 6 8}

Efficacy comparable to that of dorzolamide in reducing IOP in patients with open-angle glaucoma or ocular hypertension;^{1 3 6 8} less effective than timolol.⁵

Safety and efficacy not established for the treatment of acute angle-closure glaucoma.¹

Azopt Dosage and Administration

Administration

For topical ophthalmic use only.¹ Not for injection or oral use.¹

Ophthalmic Administration

Apply topically to the affected eye(s) as an ophthalmic suspension.¹

Shake suspension well prior to use.¹

Avoid contamination of the suspension container.¹

If more than one topical ophthalmic drug is used, administer the drugs at least 10 minutes apart.¹

Dosage

Adults

Ocular Hypertension and Glaucoma

Ophthalmic

One drop of a 1% suspension in the affected eye(s) 3 times daily.¹

Cautions for Azopt

Contraindications

• 
  

  Known hypersensitivity to brinzolamide or any ingredient in the formulation.¹

  
  

Warnings/Precautions

Sensitivity Reactions

Sulfonamide Sensitivity Reactions

Serious adverse events (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anemia, other blood dyscrasias) associated with sulfonamide therapy possible.¹

Usual precautions associated with systemic use of sulfonamides apply.¹ Discontinue brinzolamide if serious reactions or signs or symptoms of hypersensitivity occur.¹

General Precautions

Ocular Effects

Effect on corneal endothelium not fully evaluated.¹

Specific Populations

Pregnancy

Category C.¹

Lactation

Distributed into milk in rats following oral administration; not known whether distributed into human milk following topical application to eye.¹ Discontinue nursing or the drug.¹

Pediatric Use

Safety and efficacy not established.^{1 9}

Geriatric Use

No overall differences in safety and efficacy relative to younger adults.¹

Hepatic Impairment

Not studied in patients with hepatic impairment; use with caution.¹

Renal Impairment

Not studied in patients with severe renal impairment (Cl_cr< 30 mL/minute).¹ Not recommended in such patients, since brinzolamide and its metabolite are excreted mainly by the kidneys.¹

Common Adverse Effects

Blurred vision, taste disturbances (bitter, sour, or unusual taste).¹

Interactions for Azopt

Specific Drugs

Drug	Interaction	Comments
Carbonic anhydrase inhibitors, oral	Additive systemic effects1	Concomitant use not recommended1
Ocular hypotensive agents	Additive IOP-lowering effects1	Used to therapeutic advantage1
Salicylates	Rare reports of toxicity associated with acid-base disturbances in patients receiving oral carbonic anhydrase inhibitors with high-dose salicylates1	Consider possibility of similar interaction with ophthalmic brinzolamide1

Azopt Pharmacokinetics

Absorption

Bioavailability

Absorbed into systemic circulation following topical application to eye.¹

Distribution

Extent

Brinzolamide accumulates in erythrocytes due to carbonic anhydrase-II (CA-II) binding; N-desmethyl metabolite accumulates in erythrocytes due to CA-I binding.¹

Plasma Protein Binding

60%.¹

Elimination

Metabolism

Not fully characterized.¹

Elimination Route

Brinzolamide and N-desmethyl brinzolamide are eliminated in urine.¹

Half-life

Brinzolamide: 111 days in whole blood.¹

Stability

Storage

Ophthalmic

Suspension

4–30°C.¹

ActionsActions

• 
  

  Potent ocular hypotensive agent; can produce mean IOP reductions of about 16–19% in patients with elevated IOP.^{1 3 8}

  
  


• 
  

  Highly specific inhibitor of CA-II, the main carbonic anhydrase isoenzyme involved in aqueous humor secretion.^{1 2 3} Inhibition of carbonic anhydrase in the ciliary process of the eye decreases the rate of aqueous humor secretion and IOP by slowing bicarbonate formation and reducing sodium and fluid transport.^{1 2}

  
  


• 
  

  Accumulates in erythrocytes as a result of CA-II binding; however, sufficient CA-II activity remains so that adverse effects resulting from systemic carbonic anhydrase inhibition are not observed.^{1 5}

  
  

Advice to Patients

• 
  

  Risk of adverse effects, including sensitivity reactions; discontinue therapy and consult clinician if serious or unusual ocular or systemic reactions or signs of sensitivity occur.¹

  
  


• 
  

  Risk of temporary blurring of vision; use caution when driving or operating machinery.¹

  
  


• 
  

  Importance of learning and adhering to proper administration techniques to avoid contamination of the product.¹

  
  


• 
  

  Importance of informing clinicians if an intercurrent ocular condition (e.g., trauma, infection) develops or ocular surgery is planned.¹

  
  


• 
  

  Importance of administering different topical ophthalmic preparations at least 10 minutes apart.¹

  
  


• 
  

  Importance of removing soft contact lenses prior to administering the drug and of delaying reinsertion of the lenses for at least 15 minutes after administration.¹

  
  


• 
  

  Importance of patients informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs.¹

  
  


• 
  

  Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.¹

  
  


• 
  

  Importance of informing patient of other important precautionary information.¹ (See Cautions.)

  
  

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Brinzolamide

Routes	Dosage Forms	Strengths	Brand Names	Manufacturer
Ophthalmic	Suspension	1%	Azopt (with benzalkonium chloride)	Alcon

Comparative Pricing

This pricing information is subject to change at the sole discretion of DS Pharmacy. This pricing information was updated 03/2011. Actual costs to patients will vary depending on the use of specific retail or mail-order locations and health insurance copays.

Azopt 1% Suspension (ALCON VISION): 10/$119.99 or 30/$336.98

Azopt 1% Suspension (ALCON VISION): 15/$161.99 or 45/$461.98

Disclaimer

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS Drug Information. © Copyright, 1959-2011, Selected Revisions July 2007. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.

References

1. Alcon. Azopt (brinzolamide) ophthalmic suspension 1% prescribing information. Fort Worth, TX; 2003 Dec.

2. DeSantis L. Preclinical overview of brinzolamide. Surv Ophthalmol. 2000; 44(Suppl 2):119-29.

3. Silver LH and the Brinzolamide Primary Therapy Study Group. Clinical efficacy and safety of brinzolamide (Azopt), a new topical carbonic anhydrase inhibitor for primary open-angle glaucoma and ocular hypertension. Am J Ophthalmol. 1998; 126:400-8. [IDIS 414483] [PubMed 9744373]

4. Shin D and the Brinzolamide Adjunctive Therapy Study Group. Adjunctive therapy with brinzolamide 1% ophthalmic suspension (Azopt) in patients with open-angle glaucoma or ocular hypertension maintained on timolol therapy. Surv Ophthalmol. 2000; 44(Suppl 2):163-8.

5. March WF, Ochsner KI and the Brinzolamide Long-Term Therapy Study Group. The long-term safety and efficacy of brinzolamide 1.0% (Azopt) in patients with primary open-angle glaucoma or ocular hypertension. Am J Ophthalmol. 2000; 129:136-43. [IDIS 442914] [PubMed 10682964]

6. Anon. Brinzolamide-a new topical carbonic anhydrase inhibitor for glaucoma. Med Lett Drugs Ther. 1998; 40:95-6. [PubMed 9774966]

7. Ingram CJ, Brubaker RF. Effect of brinzolamide and dorzolamide on aqueous humor flow in human eyes. Am J Ophthalmol. 1999; 128:292-6. [IDIS 435005] [PubMed 10511022]

8. Sall K and the Brinzolamide Primary Therapy Study Group. The efficacy and safety of brinzolamide 1% ophthalmic suspension (Azopt) as a primary therapy in patients with open-angle glaucoma or ocular hypertension. Surv Ophthalmol. 2000; 44(Suppl 2):155-62.

9. Alcon, Fort Worth, TX: Personal communication.

More Azopt resources

• Azopt Side Effects (in more detail)
• Azopt Dosage
• Azopt Use in Pregnancy & Breastfeeding
• Azopt Drug Interactions
• Azopt Support Group
• 0 Reviews for Azopt - Add your own review/rating

• Azopt Prescribing Information (FDA)


• Azopt Concise Consumer Information (Cerner Multum)


• Azopt Advanced Consumer (Micromedex) - Includes Dosage Information


• Azopt Drops MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Azopt with other medications

• Glaucoma, Open Angle
• Intraocular Hypertension

Aquachloral Supprettes Suppositories

Generic Name: Chloral Hydrate (KLOR-uhl HYE-drate)
Brand Name: Aquachloral Supprettes

Aquachloral Supprettes Suppositories are used for:

Treating sleep disorders. It may be used to prevent symptoms of alcohol withdrawal or to treat existing withdrawal symptoms. It may also be used to produce sedation or sleep before certain procedures, or to relieve anxiety due to certain procedures or substance withdrawal. It may also be used along with other medicines after surgery to help decrease pain. It may also be used for other conditions as determined by your doctor.

Aquachloral Supprettes Suppositories are a nonbarbiturate sedative and hypnotic. It works by depressing the central nervous system (brain). This causes drowsiness and helps you to fall asleep. It is less likely to cause a slower breathing rate than barbiturate-type sedatives/hypnotics.

Do NOT use Aquachloral Supprettes Suppositories if:

• you are allergic to any ingredient in Aquachloral Supprettes Suppositories


• you have moderate to severe liver or kidney problems, severe heart problems, or severe inflammation of your stomach or rectum


• you are currently taking dofetilide, H₁ antagonists (eg, astemizole, terfenadine), or sodium oxybate (GHB)


• you have a history of alcohol or other substance abuse or dependence

Contact your doctor or health care provider right away if any of these apply to you.

Before using Aquachloral Supprettes Suppositories:

Some medical conditions may interact with Aquachloral Supprettes Suppositories. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have an inflammation of the esophagus, an ulcer, a blood disorder (eg, porphyria), suicidal thoughts, or you have a history of depression

Some MEDICINES MAY INTERACT with Aquachloral Supprettes Suppositories. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Arsenic, cisapride, dofetilide, or H₁ antagonists (eg, astemizole, terfenadine) because side effects, such as serious heart problems, may occur


• Barbiturates (eg, phenobarbital), paraldehyde, or sodium oxybate (GHB) because the actions and side effects of these medicines may be increased


• Loop diuretics (eg, furosemide) because unexpected side effects, such as fast heart rate and changing blood pressure, may occur


• Anticoagulants (eg, warfarin) because actions and side effects may be altered by Aquachloral Supprettes Suppositoriess

This may not be a complete list of all interactions that may occur. Ask your health care provider if Aquachloral Supprettes Suppositories may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Aquachloral Supprettes Suppositories:

Use Aquachloral Supprettes Suppositories as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• If the suppository is too soft to use, run cold water over it. Then remove the wrapper and moisten the suppository with cool water. Lie down on your side. Insert the pointed end of the suppository into the rectum, then use your finger to push it in completely. Wash your hands thoroughly after using Aquachloral Supprettes Suppositories.


• If you miss a dose of Aquachloral Supprettes Suppositories and you are taking it regularly, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Aquachloral Supprettes Suppositories.

Important safety information:

• Aquachloral Supprettes Suppositories may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Aquachloral Supprettes Suppositories. Using Aquachloral Supprettes Suppositories alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.


• Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Aquachloral Supprettes Suppositories. Aquachloral Supprettes Suppositories will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.


• Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Aquachloral Supprettes Suppositories.


• Aquachloral Supprettes Suppositories may contain tartrazine dye (FD&C Yellow No. 5), which can cause allergic reactions in certain patients. If you have previously had an allergic reaction to tartrazine, contact your pharmacist to determine if the medicine you are taking contains tartrazine.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Aquachloral Supprettes Suppositories during pregnancy. Aquachloral Supprettes Suppositories are excreted in breast milk. If you are or will be breast-feeding while you are using Aquachloral Supprettes Suppositories, check with your doctor or pharmacist to discuss the risks to your baby.

Aquachloral Supprettes Suppositories may be habit-forming and lead to DEPENDENCE if used in high doses or for a long period of time. If you are on long-term or high dosage therapy, you may have WITHDRAWAL symptoms (eg, convulsions, tremor, stomach and muscle cramps, vomiting, sweating) if you suddenly stop taking Aquachloral Supprettes Suppositories. Do not stop therapy abruptly or change dosage without asking your pharmacist or doctor. Discuss overuse with your doctor or pharmacist.

Possible side effects of Aquachloral Supprettes Suppositories:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; drowsiness upon awakening; gas; nausea; unpleasant taste in mouth; upset stomach.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); disorientation; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Aquachloral Supprettes side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include decreased pupil size; slow or fast and shallow breathing; vomiting.

Proper storage of Aquachloral Supprettes Suppositories:

Store Aquachloral Supprettes Suppositories at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly closed container. Do not refrigerate. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Aquachloral Supprettes Suppositories out of the reach of children and away from pets.

General information:

• If you have any questions about Aquachloral Supprettes Suppositories, please talk with your doctor, pharmacist, or other health care provider.


• Aquachloral Supprettes Suppositories are to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Aquachloral Supprettes Suppositories. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Aquachloral Supprettes resources

• Aquachloral Supprettes Side Effects (in more detail)
• Aquachloral Supprettes Use in Pregnancy & Breastfeeding
• Aquachloral Supprettes Drug Interactions
• Aquachloral Supprettes Support Group
• 1 Review for Aquachloral Supprettes - Add your own review/rating

Compare Aquachloral Supprettes with other medications

• Insomnia
• Sedation

MZM

Generic Name: methazolamide (meth a ZOLE a mide)

Brand Names: Glauctabs, MZM, Neptazane

What is MZM (methazolamide)?

Methazolamide is a carbonic anhydrase inhibitor. Carbonic anhydrase is a protein in the body. Methazolamide reduces the activity of this protein.

Methazolamide is used to treat glaucoma. By inhibiting the actions of carbonic anhydrase, methazolamide reduces the amount of fluid produced in the eyes and therefore also reduces pressure.

Methazolamide may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about MZM (methazolamide)?

Contact your doctor immediately if you experience a sore throat, fever, unusual bleeding or bruising, tingling or tremors in the hands or feet, pain in the side or groin, or a rash. These symptoms could be early signs of a serious side effect.

Use caution when driving, operating machinery, or performing other hazardous activities. Methazolamide may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Avoid prolonged exposure to sunlight. Methazolamide may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.

What should I discuss with my healthcare provider before taking MZM (methazolamide)?

Tell your doctor if you have ever had an allergic reaction to a sulfa-based drug such as sulfamethoxazole (e.g., Bactrim, Septra, Gantanol). Methazolamide is also a sulfa-based drug, and you may have a similar reaction to it.

Before taking methazolamide, tell your doctor if you

• 
  

  are on aspirin therapy,

  
  


• 
  

  have liver disease,

  
  


• 
  

  have kidney disease,

  
  


• 
  

  have heart disease,

  
  


• 
  

  have lung disease, or

  
  


• 
  

  have a hormonal disease.

  
  

You may not be able to take methazolamide, or you may require a dosage adjustment special monitoring during treatment if you have any of the conditions listed above.

Methazolamide is in the FDA pregnancy category C. This means that it is not known whether methazolamide will be harm an unborn baby. Do not take methazolamide without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether methazolamide passes into breast . Do not take methazolamide without first talking to your doctor if you are breast-feeding a baby.

How should I take MZM (methazolamide)?

Take methazolamide exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. Take methazolamide with food if it causes stomach upset.

It is important to take methazolamide regularly to get the most benefit.

Store methazolamide at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention if an overdose is suspected.

Symptoms of a methazolamide overdose include drowsiness, decreased appetite, nausea, vomiting, dizziness, numbness or tingling, shaking, and ringing in the ears.

What should I avoid while taking MZM (methazolamide)?

Use caution when driving, operating machinery, or performing other hazardous activities. Methazolamide may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Avoid prolonged exposure to sunlight. Methazolamide may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.

MZM (methazolamide) side effects

If you experience any of the following serious side effects, stop taking methazolamide and seek emergency medical attention or contact your doctor immediately:

• 
  

  an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

  
  


• 
  

  a sore throat or a fever;

  
  


• 
  

  unusual bleeding or bruising;

  
  


• 
  

  side or groin pain;

  
  


• 
  

  tingling or tremors in the hands or feet; or

  
  


• 
  

  a rash.

  
  

Other, less serious side effects may be more likely to occur. Continue to take methazolamide and talk to your doctor if you experience

• 
  

  decreased appetite, nausea, vomiting, constipation, diarrhea, or changes in taste;

  
  


• 
  

  drowsiness, dizziness, fatigue, or weakness;

  
  


• 
  

  nervousness or tremor;

  
  


• 
  

  headache or confusion;

  
  


• 
  

  increased sensitivity of the skin to sunlight;

  
  


• 
  

  worsening gout;

  
  


• 
  

  loss of blood sugar control (if you are diabetic);

  
  


• 
  

  ringing in your ears or hearing problems; or

  
  


• 
  

  changes in vision.

  
  

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect MZM (methazolamide)?

Before taking this medication, tell your doctor if you are taking any of the following medicines:

• 
  

  cyclosporine (Sandimmune);

  
  


• 
  

  primidone (Mysoline);

  
  


• 
  

  diflunisal (Dolobid;

  
  


• 
  

  aspirin, salsalate (Disalcid, Salflex, Salsitab, others), choline salicylate (Arthropan), magnesium salicylate (Doan's, Magan, Mobidin), or other aspirin-like products (salicylates); or

  
  


• 
  

  lithium (Lithobid, Eskalith, others).

  
  

You may not be able to take methazolamide, or you may require a dosage adjustment or special monitoring during treatment.

Drugs other than those listed here may also interact with methazolamide. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

More MZM resources

• MZM Side Effects (in more detail)
• MZM Use in Pregnancy & Breastfeeding
• MZM Drug Interactions
• 0 Reviews for MZM - Add your own review/rating

• Methazolamide Prescribing Information (FDA)


• Methazolamide MedFacts Consumer Leaflet (Wolters Kluwer)


• Methazolamide Professional Patient Advice (Wolters Kluwer)


• Methazolamide Monograph (AHFS DI)


• Neptazane Prescribing Information (FDA)

Compare MZM with other medications

• Glaucoma

Where can I get more information?

• Your pharmacist has more information about methazolamide written for health professionals that you may read.

See also: MZM side effects (in more detail)

Cambia

Generic Name: diclofenac (Oral route)

dye-KLOE-fen-ak

Oral route(Tablet, Enteric Coated;Tablet, Extended Release)

NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may be increased in patients with cardiovascular disease or risk factors for cardiovascular disease. Diclofenac is contraindicated for the treatment of peri-operative pain in the setting of CABG surgery. NSAIDs can also cause an increased risk of serious gastrointestinal adverse events especially in the elderly, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal .

Oral route(Tablet;Capsule, Liquid Filled;Powder for Solution)

NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may be increased in patients with cardiovascular disease or risk factors for cardiovascular disease. Diclofenac is contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery. NSAIDs can also cause an increased risk of serious gastrointestinal adverse events especially in the elderly, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal .

Commonly used brand name(s)

In the U.S.

• Cambia


• Cataflam


• Voltaren


• Voltaren-XR


• Zipsor

Available Dosage Forms:

• Tablet, Enteric Coated


• Tablet, Extended Release


• Capsule


• Powder for Solution


• Capsule, Liquid Filled


• Tablet

Therapeutic Class: Analgesic

Pharmacologic Class: NSAID

Chemical Class: Acetic Acid (class)

Uses For Cambia

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild-to-moderate pain, and helps to relieve symptoms of arthritis (e.g., osteoarthritis or rheumatoid arthritis), such as inflammation, swelling, stiffness, and joint pain. This medicine does not cure arthritis and will only help you as long as you continue to take it.

This medicine is also used to treat ankylosing spondylitis, which is a type of arthritis that affects the joints in the spine, and other painful conditions such as menstrual cramps.

Diclofenac is also used to treat acute migraine attacks, with or without aura, in adults. It will not prevent or lessen the number of migraine attacks.

This medicine is available only with your doctor's prescription.

Before Using Cambia

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of diclofenac in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of diclofenac in the elderly. However, elderly patients are more likely to have age-related kidney or stomach problems, which may require caution for patients receiving diclofenac.

Pregnancy

	Pregnancy Category	Explanation
1st Trimester	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.
2nd Trimester	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.
3rd Trimester	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Ketorolac


• Pentoxifylline

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abciximab


• Ardeparin


• Argatroban


• Beta Glucan


• Bivalirudin


• Certoparin


• Cilostazol


• Citalopram


• Clopidogrel


• Clovoxamine


• Dabigatran Etexilate


• Dalteparin


• Danaparoid


• Desirudin


• Dipyridamole


• Enoxaparin


• Escitalopram


• Femoxetine


• Flesinoxan


• Fluoxetine


• Fluvoxamine


• Fondaparinux


• Ginkgo


• Heparin


• Lepirudin


• Methotrexate


• Nadroparin


• Nefazodone


• Parnaparin


• Paroxetine


• Pemetrexed


• Protein C


• Reviparin


• Rivaroxaban


• Sertraline


• Sibutramine


• Tacrolimus


• Ticlopidine


• Tinzaparin


• Tirofiban


• Vilazodone


• Zimeldine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acebutolol


• Acetohexamide


• Alacepril


• Alprenolol


• Amiloride


• Arotinolol


• Atenolol


• Azilsartan Medoxomil


• Azosemide


• Befunolol


• Bemetizide


• Benazepril


• Bendroflumethiazide


• Benzthiazide


• Betaxolol


• Bevantolol


• Bisoprolol


• Bopindolol


• Bucindolol


• Bumetanide


• Bupranolol


• Buthiazide


• Candesartan Cilexetil


• Canrenoate


• Captopril


• Carteolol


• Carvedilol


• Celiprolol


• Chlorothiazide


• Chlorpropamide


• Chlorthalidone


• Cholestyramine


• Cilazapril


• Ciprofloxacin


• Clopamide


• Colestipol


• Cyclopenthiazide


• Cyclosporine


• Delapril


• Desvenlafaxine


• Dilevalol


• Duloxetine


• Enalaprilat


• Enalapril Maleate


• Eprosartan


• Esmolol


• Ethacrynic Acid


• Fosinopril


• Furosemide


• Gliclazide


• Glimepiride


• Glipizide


• Gliquidone


• Glyburide


• Hydrochlorothiazide


• Hydroflumethiazide


• Imidapril


• Indapamide


• Irbesartan


• Labetalol


• Landiolol


• Levobetaxolol


• Levobunolol


• Lisinopril


• Lithium


• Losartan


• Mepindolol


• Methyclothiazide


• Metipranolol


• Metolazone


• Metoprolol


• Milnacipran


• Moexipril


• Nadolol


• Nebivolol


• Nipradilol


• Olmesartan Medoxomil


• Oxprenolol


• Penbutolol


• Pentopril


• Perindopril


• Pindolol


• Piretanide


• Polythiazide


• Propranolol


• Quinapril


• Ramipril


• Sotalol


• Spirapril


• Spironolactone


• Talinolol


• Tasosartan


• Telmisartan


• Temocapril


• Tertatolol


• Timolol


• Tolazamide


• Tolbutamide


• Torsemide


• Trandolapril


• Triamterene


• Trichlormethiazide


• Valsartan


• Venlafaxine


• Voriconazole


• Xipamide


• Zofenopril

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Anemia or


• Asthma or


• Bleeding problems or


• Blood clots or


• Edema (fluid retention) or


• Heart attack, history of or


• Heart disease (e.g., congestive heart failure) or


• Hepatitis, history of or


• Hypertension (high blood pressure) or


• Kidney disease or


• Porphyria (blood disorder) or


• Stomach ulcers or bleeding, history of or


• Stroke, history of—Use with caution. May make these conditions worse.

• Aspirin-sensitive asthma, history of—This medicine should not be used in patients with this condition.

• Heart surgery (e.g., coronary artery bypass graft [CABG] surgery)—This medicine should not be used to relieve pain right before or after the surgery.

• Liver disease—Use with caution. Effects may be increased because of slower removal of the medicine from the body.

• Phenylketonuria (PKU)—The oral powder for solution contains phenylalanine, which can make this condition worse.

Proper Use of diclofenac

This section provides information on the proper use of a number of products that contain diclofenac. It may not be specific to Cambia. Please read with care.

For the safe and effective use of this medicine, do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Taking too much of this medicine may increase the chance of unwanted effects.

This medicine should come with a medication guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

When used for severe or continuing arthritis, this medicine must be taken every day as ordered by your doctor in order for it to help you. This medicine usually begins to work within one week, but in severe cases up to two weeks or longer may pass before you begin to feel better. Several weeks may pass before you feel the full effects of this medicine.

You may take this medicine with or without food.

To use the oral solution:

• Open the packet of medicine right before you use it.


• Empty the contents of the packet into a cup with 1 to 2 ounces (30 to 60 milliliters [mL]) of water. Do not use any liquid other than water for mixing the medicine.


• Mix well and drink it immediately on an empty stomach.

Use only the brand of this medicine that your doctor prescribed. Different brands may not work the same way.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage forms (delayed-release tablets, enteric-coated tablets):
  
  • For ankylosing spondylitis:
    
    • Adults—25 milligrams (mg) four times a day, with an extra 25 mg dose at bedtime if necessary.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • For osteoarthritis:
    
    • Adults—50 milligrams (mg) two or three times a day, or 75 mg two times a day.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • For rheumatoid arthritis:
    
    • Adults—50 milligrams (mg) three or four times a day, or 75 mg two times a day.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

• For oral dosage form (immediate-release tablets):
  
  • For osteoarthritis:
    
    • Adults—50 milligrams (mg) two or three times a day.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • For pain or menstrual cramps:
    
    • Adults—50 milligrams (mg) three times a day. Your doctor may direct you to take 100 mg for the first dose only.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • For rheumatoid arthritis:
    
    • Adults—50 milligrams (mg) three or four times a day.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

• For oral dosage form (solution):
  
  • For migraine headaches:
    
    • Adults—One packet (50 milligrams) as a single, one time dose.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Cambia

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood and urine tests may be needed to check for unwanted effects.

This medicine may raise your risk of having a heart attack or stroke. This is more likely in people who already have heart disease. People who use this medicine for a long time might also have a higher risk.

This medicine may cause bleeding in your stomach or intestines. These problems can happen without warning signs. This is more likely if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, are over 60 years of age, are in poor health, or are using certain medicines (such as a steroid medicine or a blood thinner).

Serious skin reactions can occur during treatment with this medicine. Check with your doctor right away if you have any of the following symptoms while taking this medicine: blistering, peeling, loosening of the skin; chills; cough; diarrhea; fever; itching; joint or muscle pain; red skin lesions; sore throat sores, ulcers, or white spots in the mouth or on the lips; or unusual tiredness or weakness.

Some possible warning signs of serious side effects that can occur with this medicine may include black, tarry stools; decreased urination; severe stomach pain; skin rash; swelling of the face, fingers, feet, and/or lower legs; unusual bleeding or bruising; unusual weight gain; vomiting of blood or material that looks like coffee grounds; or yellow skin or eyes; . Also, signs of serious heart problems could occur, such as chest pain, fast or irregular heartbeat, tightness in the chest, unusual flushing or warmth of the skin, weakness, or slurring of speech. Stop taking this medicine and check with your doctor right away if you notice any of these warning signs.

This medicine may also cause a serious type of allergic reaction called anaphylaxis. Although this is rare, it may occur more often in patients who are allergic to aspirin or nonsteroidal antiinflammatory drugs (NSAIDs). Anaphylaxis can be life-threatening and requires immediate medical attention. The most serious signs of this reaction are very fast or irregular breathing, gasping for breath, wheezing, or fainting. Other signs may include changes in color of the skin of the face; very fast but irregular heartbeat or pulse; hive-like swellings on the skin; and puffiness or swelling of the eyelids or around the eyes. If these effects occur, get emergency help at once.

Using this medicine while you are pregnant can harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away.

Call your doctor right away if you have confusion, drowsiness, fever, general feeling of illness, headache, loss of appetite, nausea, stiff neck or back, or vomiting. These could be symptoms of meningitis.

Check with your doctor immediately if blurred vision, difficulty in reading, or any other change in vision occurs during or after your treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

Before having any kind of surgery or medical tests, tell your doctor that you are taking this medicine. It may be necessary for you to stop treatment for awhile, or to change to a different nonsteroidal antiinflammatory drug before your procedure.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Cambia Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Abdominal or stomach bloating, burning, cramping, or pain


• belching


• bloody or black, tarry stools


• cloudy urine


• constipation


• decrease in urine output or decrease in urine-concentrating ability


• diarrhea


• dizziness


• feeling of indigestion


• headache


• increased bleeding time


• itching skin


• loss of appetite


• nausea and vomiting


• pain in the chest below the breastbone


• pale skin


• rash


• severe stomach pain


• swelling


• troubled breathing with exertion


• unusual bleeding or bruising


• unusual tiredness or weakness


• vomiting of blood or material that looks like coffee grounds


• weight loss

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Agitation


• blurred vision


• change in the ability to see colors, especially blue or yellow


• change in consciousness


• confusion


• depression


• difficult or troubled breathing


• hives


• hostility


• insomnia


• irregular, fast or slow, or shallow breathing


• irritability


• loss of consciousness


• muscle twitching


• nervousness


• pain or discomfort in the chest, upper stomach, or throat


• pale or blue lips, fingernails, or skin


• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• rapid weight gain


• seizures


• shortness of breath


• sleepiness


• slow or fast heartbeat


• stupor


• swelling of the face, ankles, or hands


• tightness in the chest


• unusual drowsiness, dullness, or feeling of sluggishness


• wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Bloated, full feeling


• continuing ringing or buzzing or other unexplained noise in the ears


• excess air or gas in stomach or intestines


• hearing loss


• lack or loss of strength


• passing gas

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Cambia side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Cambia resources

• Cambia Side Effects (in more detail)
• Cambia Use in Pregnancy & Breastfeeding
• Cambia Drug Interactions
• Cambia Support Group
• 2 Reviews for Cambia - Add your own review/rating

• Cambia Consumer Overview


• Cambia Prescribing Information (FDA)


• Cambia Powder Packets MedFacts Consumer Leaflet (Wolters Kluwer)


• Diclofenac Professional Patient Advice (Wolters Kluwer)


• Diclofenac Prescribing Information (FDA)


• Diclofenac MedFacts Consumer Leaflet (Wolters Kluwer)


• Cataflam Prescribing Information (FDA)


• Cataflam Consumer Overview


• Cataflam Immediate-Release Tablets MedFacts Consumer Leaflet (Wolters Kluwer)


• Voltaren Prescribing Information (FDA)


• Voltaren Drops MedFacts Consumer Leaflet (Wolters Kluwer)


• Voltaren Consumer Overview


• Zipsor Prescribing Information (FDA)


• Zipsor Consumer Overview


• diclofenac epolamine Monograph (AHFS DI)

Compare Cambia with other medications

• Migraine

Aspirin/Oxycodone

Pronunciation: OX-i-KOE-done/AS-pir-in
Generic Name: Oxycodone/Aspirin
Brand Name: Examples include Endodan and Percodan

Aspirin/Oxycodone is used for:

Treating moderate to moderately severe pain.

Aspirin/Oxycodone is a narcotic pain reliever and salicylate combination. The narcotic works in the brain to reduce pain. The salicylate works by blocking certain chemicals in the body that cause pain and inflammation.

Do NOT use Aspirin/Oxycodone if:

• you are allergic to any ingredient in Aspirin/Oxycodone or to a nonsteroidal anti-inflammatory drug (NSAID) (eg, ibuprofen, naproxen, celecoxib)


• you have had asthma symptoms (eg, shortness of breath, wheezing), nasal swelling, or growths in the nose caused by aspirin


• you have moderate to severe breathing problems, severe asthma, or you are having an asthma attack


• you have a history of certain bleeding problems (eg, hemophilia, von Willebrand disease), low blood platelet levels, stomach ulcers, or you have severe bleeding


• you have known or suspected bowel blockage (paralytic ileus) or you have severe or persistent diarrhea caused by antibiotics


• the patient is a child with a viral infection (eg, chickenpox, flu symptoms)


• you are taking sodium oxybate (GHB) or ketorolac

Contact your doctor or health care provider right away if any of these apply to you.

Before using Aspirin/Oxycodone:

Some medical conditions may interact with Aspirin/Oxycodone. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you are allergic to other narcotic pain relievers (eg, morphine, codeine, hydromorphone)


• if you have a history of constipation, lung or breathing problems (eg, asthma, emphysema, bronchitis, chronic obstructive pulmonary disease [COPD]), sleep apnea (you stop breathing when you sleep), curvature of the spine (eg, kyphoscoliosis), heart problems (eg, cor pulmonale), low blood pressure, dehydration, low blood volume, or shock caused by heart problems


• if you have a history of recent head injury, growths in the brain (eg, tumors, lesions), an enlarged blood vessel in the brain (eg, aneurysm), increased pressure in the brain, stroke, or seizures (eg, epilepsy)


• if you have blood problems (eg, porphyria), bleeding or clotting problems, low levels of vitamin K in the blood, chickenpox or flu symptoms, hives, Kawasaki syndrome, a rheumatic condition, or severe drowsiness


• if you have a history of kidney or liver problems, thyroid problems, stomach or bowel problems (eg, ulcers, inflammation, recent surgery), pancreas or gallbladder problems, adrenal problems (Addison disease), an enlarged prostate, blockage of your bladder, or trouble urinating


• if you have a history of mood or mental problems (eg, depression, hallucinations), suicidal thoughts or behavior, alcohol or other substance abuse, regular alcohol use, or if you are in alcohol withdrawal


• if you are in poor health or will be having surgery

Some MEDICINES MAY INTERACT with Aspirin/Oxycodone. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, heparin, warfarin, enoxaparin), clopidogrel, dabigatran, desirudin, NSAIDs (eg, ibuprofen, ketorolac), rivaroxaban, or selective serotonin reuptake inhibitors (SSRIs) (eg, citalopram) because the risk of bleeding or ulcers may be increased


• Certain antinausea medicines (eg, metoclopramide), azole antifungals (eg, ketoconazole), cimetidine, HIV protease inhibitors (eg, ritonavir), macrolide antibiotics (eg, clarithromycin), muscle relaxants (eg, cyclobenzaprine), narcotic pain relievers (eg, codeine), nefazodone, phenothiazines (eg, chlorpromazine), sodium oxybate (GHB), or telithromycin because the risk of serious side effects, such as severe drowsiness or slow or difficult breathing, may be increased


• Mixed narcotic agonists/antagonists (eg, buprenorphine, butorphanol, nalbuphine, pentazocine), naltrexone, or rifamycins (eg, rifampin) because they may decrease Aspirin/Oxycodone's effectiveness


• Carbonic anhydrase inhibitors (eg, acetazolamide), insulin, methotrexate, oral diabetes medicines (eg, glyburide, repaglinide), phenytoin, or valproic acid because the risk of their side effects may be increased by Aspirin/Oxycodone


• Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), beta-blockers (eg, propranolol), diuretics (eg, furosemide, hydrochlorothiazide), probenecid, or sulfinpyrazone because their effectiveness may be decreased by Aspirin/Oxycodone

This may not be a complete list of all interactions that may occur. Ask your health care provider if Aspirin/Oxycodone may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Aspirin/Oxycodone:

Use Aspirin/Oxycodone as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Aspirin/Oxycodone by mouth with or without food. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.


• Do not change your dose or suddenly stop taking Aspirin/Oxycodone without first checking with your doctor.


• If Aspirin/Oxycodone is no longer needed, dispose of it as soon as possible. Ask your doctor or pharmacist how to dispose of Aspirin/Oxycodone properly.


• If you miss a dose of Aspirin/Oxycodone and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Aspirin/Oxycodone.

Important safety information:

• Aspirin/Oxycodone may cause drowsiness, dizziness, lightheadedness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Aspirin/Oxycodone with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Check with your doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Aspirin/Oxycodone; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.


• Aspirin/Oxycodone may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.


• The risk of serious breathing problems may be greater if you take Aspirin/Oxycodone in high doses. Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.


• Aspirin/Oxycodone may cause stomach bleeding. Your risk may be greater if you drink alcohol while you are using Aspirin/Oxycodone.


• Aspirin/Oxycodone may cause or worsen constipation. To prevent constipation, maintain a diet adequate in fiber, drink plenty of water, and exercise. If you become constipated while taking Aspirin/Oxycodone, talk with your doctor or pharmacist. A stool softener or fiber laxative may be required.


• Talk to your doctor before you take Aspirin/Oxycodone if you drink 3 or more drinks with alcohol per day.


• Aspirin/Oxycodone may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.


• Aspirin has been linked to a serious illness called Reye syndrome. Do not give Aspirin/Oxycodone to a child or teenager who has the flu, chickenpox, or a viral infection. Do not give Aspirin/Oxycodone to a child or teenager who has recently received a flu or chickenpox vaccine. Contact your doctor with any questions or concerns.


• Tell your doctor or dentist that you take Aspirin/Oxycodone before you receive any medical or dental care, emergency care, or surgery.


• Aspirin/Oxycodone has aspirin in it. Before you start any new medicine, check the label to see if it has aspirin or another salicylate in it too. If it does or if you are not sure, check with your doctor or pharmacist.


• If you are taking aspirin prescribed by your doctor to prevent heart attack or stroke, check with your doctor to see whether you should continue to take it with Aspirin/Oxycodone


• Diabetes patients - Aspirin/Oxycodone may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.


• Aspirin/Oxycodone may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Aspirin/Oxycodone.


• Use Aspirin/Oxycodone with caution in the ELDERLY; they may be more sensitive to its effects, especially breathing problems.


• Aspirin/Oxycodone should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Aspirin/Oxycodone has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Aspirin/Oxycodone while you are pregnant. Avoid using Aspirin/Oxycodone during the last 3 months of pregnancy. Aspirin/Oxycodone is found in breast milk. Do not breast-feed while taking Aspirin/Oxycodone.

When used for long periods of time or at high doses, Aspirin/Oxycodone may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Aspirin/Oxycodone stops working well. Do not take more than prescribed.

Some people who use Aspirin/Oxycodone for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction.

If you suddenly stop taking Aspirin/Oxycodone, you may have WITHDRAWAL symptoms. These may include anxiety, backache, chills, diarrhea, enlarged pupils, fast breathing, fast heartbeat, increased tearing, irritability, joint pain, loss of appetite, muscle pain, nausea, restlessness, runny nose, stomach cramps, sweating, trouble sleeping, vomiting, weakness, or yawning.

Possible side effects of Aspirin/Oxycodone:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; heartburn; lightheadedness; nausea; stomach upset; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bloody or black stools; confusion; dark urine; decreased or difficult urination; fainting; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; hallucination; hearing loss; mood or mental changes; muscle pain, weakness, or cramps; one-sided weakness; ringing in the ears; seizures; severe dizziness, drowsiness, headache, or lightheadedness; severe or persistent constipation, heartburn, or stomach pain; shortness of breath; slow or shallow breathing; trouble swallowing; unusual bruising or bleeding; vision or speech problems; vomit that looks like coffee grounds; wheezing; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Aspirin/Oxycodone side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include chest pain; cold and clammy skin; coma; confusion; dehydration; depression; enlarged or decreased pupil size; fever; loss of consciousness; ringing in the ears or trouble hearing; severe drowsiness, dizziness, lightheadedness, nausea, vomiting, or diarrhea; severe weakness; slow, shallow, or difficult breathing; slow heartbeat.

Proper storage of Aspirin/Oxycodone:

Store Aspirin/Oxycodone at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Aspirin/Oxycodone out of the reach of children and away from pets.

General information:

• If you have any questions about Aspirin/Oxycodone, please talk with your doctor, pharmacist, or other health care provider.


• Aspirin/Oxycodone is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Aspirin/Oxycodone. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Aspirin/Oxycodone resources

• Aspirin/Oxycodone Side Effects (in more detail)
• Aspirin/Oxycodone Use in Pregnancy & Breastfeeding
• Drug Images
• Aspirin/Oxycodone Drug Interactions
• Aspirin/Oxycodone Support Group
• 4 Reviews for Aspirin/Oxycodone - Add your own review/rating

Compare Aspirin/Oxycodone with other medications

• Pain